When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer

Chakravarthy, A and Henderson, S and Fenton, TR (2014) When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer. Molecular & Cellular Oncology, 1 (1). e29914 - e29914. ISSN 2372-3556. (doi:https://doi.org/10.4161/mco.29914) (Full text available)

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Abstract

The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.

Item Type: Article
Additional information: Copyright © 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
Uncontrolled keywords: APOBEC, HPV, PIK3CA, cancer, mutagenesis
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tim Fenton
Date Deposited: 25 Apr 2017 07:26 UTC
Last Modified: 08 Jun 2017 08:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61508 (The current URI for this page, for reference purposes)
Fenton, TR: https://orcid.org/0000-0002-4737-8233
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