Chakravarthy, A, Henderson, S, Fenton, TR (2014) When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer. Molecular & Cellular Oncology, 1 (1). Article Number 29914. ISSN 2372-3556. (doi:10.4161/mco.29914) (KAR id:61508)
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| Official URL: http://dx.doi.org/10.4161/mco.29914 |
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Abstract
The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.
| Item Type: | Article |
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| DOI/Identification number: | 10.4161/mco.29914 |
| Additional information: | Copyright © 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| Uncontrolled keywords: | APOBEC, HPV, PIK3CA, cancer, mutagenesis |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Tim Fenton |
| Date Deposited: | 25 Apr 2017 07:26 UTC |
| Last Modified: | 08 Jan 2022 23:11 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/61508 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Fenton, TR.
| Creator's ORCID: |
 https://orcid.org/0000-0002-4737-8233
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