APOBEC3 genes: retroviral restriction factors to cancer drivers

Henderson, S and Fenton, TR (2015) APOBEC3 genes: retroviral restriction factors to cancer drivers. Trends in Molecular Medicine, 21 (5). pp. 274-284. ISSN 1471-4914. (doi:https://doi.org/10.1016/j.molmed.2015.02.007) (Full text available)

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The APOBEC3 cytosine deaminases play key roles in innate immunity through their ability to mutagenize viral DNA and restrict viral replication. Recent advances in cancer genomics, together with biochemical characterization of the APOBEC3 enzymes, have now implicated at least two family members in somatic mutagenesis during tumor development. We review the evidence linking these enzymes to carcinogenesis and highlight key questions, including the potential mechanisms that misdirect APOBEC3 activity to the host genome, the links to viral infection, and the association between a common APOBEC3 polymorphism and cancer risk.

Item Type: Article
Additional information: © 2015. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
Uncontrolled keywords: APOBEC, cancer, mutagenesis, Animals, Carcinogenesis, Cytosine Deaminase, Humans, Immunity, Innate, Mutagenesis, Neoplasms, Retroviridae, Risk, Virus Replication
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tim Fenton
Date Deposited: 25 Apr 2017 06:55 UTC
Last Modified: 08 Jun 2017 08:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61505 (The current URI for this page, for reference purposes)
Fenton, TR: https://orcid.org/0000-0002-4737-8233
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