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Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx

Chakravarthy, A, Henderson, S, Thirdborough, SM, Ottensmeier, CH, Su, X, Lechner, M, Feber, A, Thomas, GJ, Fenton, TR (2016) Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx. Journal Of Clinical Oncology, 34 (34). pp. 4132-4141. ISSN 0732-183X. (doi:10.1200/JCO.2016.68.2955) (KAR id:61500)

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http://dx.doi.org/10.1200/JCO.2016.68.2955

Abstract

Purpose

Meta-analysis was used to build a cross-tissue gene-expression signature for HPV-driven cancer. Classifiers trained by machine-learning approaches were used to predict the HPV status of 520 HNSCCs profiled by The Cancer Genome Atlas project. DNA methylation data were similarly used to classify 464 HNSCCs and these analyses were integrated with genomic, histopathology, and survival data to permit a comprehensive comparison of HPV transcript-positive OPSCC and non-OPSCC.

Results

Our analysis identified a causal role for HPV in transcript-positive non-OPSCCs throughout the head and neck. Notably, however, HPV-driven non-OPSCCs display a distinct immune microenvironment and clinical behavior compared with HPV-driven OPSCCs.

Item Type: Article
DOI/Identification number: 10.1200/JCO.2016.68.2955
Additional information: Copyright © 2017 by American Society of Clinical Oncology. All rights reserved. Licensed under the Creative Commons Attribution 4.0 License.
Uncontrolled keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Squamous-cell Carcinoma, Active Human-papillomavirus, Gene-expression Profiles, Hpv-associated Head, Positive Head, Molecular Classification, Human Cancer, Subset, P16, Identification
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tim Fenton
Date Deposited: 21 Apr 2017 13:14 UTC
Last Modified: 29 May 2019 18:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61500 (The current URI for this page, for reference purposes)
Fenton, TR: https://orcid.org/0000-0002-4737-8233
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