Stabilizing silica nanoparticles in hydrogels: impact on storage and polydispersity

Giovannini, Giorgia and Kunc, Filip and Piras, Carmen C. and Stranik, Ondrej and Edwards, Alison A. and Hall, Andrew J. and Gubala, Vladimir (2017) Stabilizing silica nanoparticles in hydrogels: impact on storage and polydispersity. RSC Advances, 7 (32). pp. 19924-19933. ISSN 2046-2069. (doi:https://doi.org/10.1039/c7ra02427d) (Full text available)

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Abstract

For successful nanomedicine, it is important that the unique, size-dependent physico-chemical properties of the nanomaterial remain predictably constant during both the storage and the manipulation of the material. Here a novel approach to preserve the colloidal stability and degradation of NPs is described. The concept is simple: (a) a solution of monodisperse particles is formulated into a responsive water- or PBS-based hydrogel; (b) the gel can be reversibly turned into a solution after long term storage by shaking it by hand; (c) the NP can be diluted and used in any desired application without the need for excessive manipulation. The differences between the physico-chemical properties of NPs stored in solution and in gel are compared. Two types of NPs were involved in this study: silica NPs of similar100 nm and Au-NPs of 30 and 80 nm in diameter. The key findings are: the fibrous matrix of the hydrogel limits the NP mobility{,} significantly reduces NP aggregation and conserves the NP morphology; both the hydrogelator and the NPs show negligible toxicity towards the model U937 human hematopoietic cell line; undesired leaching of cargo material loaded inside the particles is reduced{,} which could be an important feature for drug delivery systems.

Item Type: Article
Subjects: Q Science
Q Science > QD Chemistry > QD473 Physical properties in relation to structure
Q Science > QD Chemistry > Analytical Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Edwards
Date Deposited: 19 Apr 2017 11:12 UTC
Last Modified: 20 Apr 2017 08:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61385 (The current URI for this page, for reference purposes)
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