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Intestinal fatty acid-binding protein and gut permeability responses to exercise

March, Daniel Scott, Marchbank, Tania, Playford, Raymond J, Jones, Arwel W, Thatcher, Rhys, Davison, Glen (2017) Intestinal fatty acid-binding protein and gut permeability responses to exercise. European Journal of Applied Physiology, 117 (5). pp. 931-941. ISSN 1439-6319. (doi:10.1007/s00421-017-3582-4)

Abstract

Purpose Intestinal cell damage due to physiological stressors (e.g. heat, oxidative, hypoperfusion/ischaemic) may contribute to increased intestinal permeability. The aim of this study was to assess changes in plasma intestinal fatty acid-binding protein (I-FABP) in response to exercise (with bovine colostrum supplementation, Col, positive control) and compare this to intestinal barrier integrity/permeability (5 h urinary lactulose/rhamnose ratio, L/R). Methods In a double-blind, placebo-controlled, crossover design, 18 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac). For each arm participants performed two baseline (resting) intestinal permeability assessments (L/R) pre-supplementation and one post-exercise following supplementation. Blood samples were collected pre- and post-exercise to determine I-FABP concentration. Results Two-way repeated measures ANOVA revealed an arm?×?time interaction for L/R and I-FABP (P?<?0.001). Post hoc analyses showed urinary L/R increased post-exercise in Plac (273% of pre, P?<?0.001) and Col (148% of pre, P?<?0.001) with post-exercise values significantly lower with Col (P?<?0.001). Plasma I-FABP increased post-exercise in Plac (191% of pre-exercise, P?=?0.002) but not in the Col arm (107%, P?=?0.862) with post-exercise values significantly lower with Col (P?=?0.013). Correlations between the increase in I-FABP and L/R were evident for visit one (P?=?0.044) but not visit two (P?=?0.200) although overall plots/patterns do appear similar for each. Conclusion These findings suggest that exercise-induced intestinal cellular damage/injury is partly implicated in changes in permeability but other factors must also contribute.

Item Type: Article
DOI/Identification number: 10.1007/s00421-017-3582-4
Uncontrolled keywords: Strenuous exercise; Intestinal permeability; Core temperature; Bovine colostrum; Cell damage; Cellular injury; Urinary L/R
Subjects: Q Science
Q Science > QP Physiology (Living systems)
R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RC Internal medicine > RC1235 Physiology of sports
Divisions: Faculties > Sciences > School of Sport and Exercise Sciences
Depositing User: Glen Davison
Date Deposited: 14 Apr 2017 19:50 UTC
Last Modified: 29 May 2019 18:57 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61352 (The current URI for this page, for reference purposes)
Davison, Glen: https://orcid.org/0000-0003-4340-0074
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