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Electromagnetic tracking of handheld high-resolution endomicroscopy probes to assist with real-time video mosaicking

Vyas, Khushi, Hughes, Michael, Yang, Guang-Zhong (2015) Electromagnetic tracking of handheld high-resolution endomicroscopy probes to assist with real-time video mosaicking. In: SPIE Proceedings Series. 9304. 93040Y. Spie-Int Soc Optical Engineering (doi:10.1117/12.2085440) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
https://doi.org/10.1117/12.2085440

Abstract

Optical fiber bundle based endomicroscopy is a low-cost optical biopsy technique for in vivo cellular level imaging. A limitation of such an imaging system, however, is its small field-of-view (FOV), typically less than 1 mm2. With such a small FOV it is difficult to associate individual image frames with the larger scale anatomical structure. Video-sequence mosaicking algorithms have been proposed as a solution for increasing the image FOV while maintaining cellular-level resolution by stitching together the endomicroscopy images. Although extensive research has focused on image processing and mosaicking algorithms, there has been limited work on localization of the probe to assist with building high quality mosaics over large areas of tissue. In this paper, we propose the use of electromagnetic (EM) navigation to assist with large-area mosaicking of hand-held high-resolution endomicroscopy probes. A six degree-of-freedom EM sensor is used to track in real-time the position and orientation of the tip of the imaging probe during free-hand scanning. We present a proof-of-principle system for EM-video data co-calibration and registration and then describe a two-step image registration algorithm that assists mosaic reconstruction. Preliminary experimental investigations are carried out on phantoms and ex vivo porcine tissue for free-hand scanning. The results demonstrate that the proposed methodology significantly improves the quality and accuracy of reconstructed mosaics compared to reconstructions based only on conventional pair-wise image registration. In principle, this approach can be applied to other optical biopsy techniques such as confocal endomicroscopy and endocytoscopy. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Item Type: Conference or workshop item (Paper)
DOI/Identification number: 10.1117/12.2085440
Uncontrolled keywords: Endomicroscopy ; Video ; Tissues ; Algorithms ; Biopsy ; Image registration ; Scanning ; Sensors ; Imaging systems ; Optical fibers
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Michael Hughes
Date Deposited: 06 Apr 2017 13:53 UTC
Last Modified: 01 Aug 2019 10:41 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61196 (The current URI for this page, for reference purposes)
Hughes, Michael: https://orcid.org/0000-0001-5301-2492
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