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The first prognostic model for stroke and death in patients with systolic heart failure

Freudenberger, Ronald S., Cheng, Bin, Mann, Douglas L., Thompson, John L.P., Sacco, Ralph L., Buchsbaum, Richard, Sanford, Alexandra, Pullicino, Patrick, Levin, Bruce, Teerlink, John R., and others. (2015) The first prognostic model for stroke and death in patients with systolic heart failure. Journal of Cardiology, 68 (2). pp. 100-103. ISSN 0914-5087. E-ISSN 1876-4738. (doi:10.1016/j.jjcc.2015.09.014) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:60688)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/j.jjcc.2015.09.014

Abstract

Background

A scoring algorithm using 8 readily obtainable clinical characteristics as predictors, age, gender, hemoglobin, blood urea nitrogen, ejection fraction, diastolic blood pressure, diabetes status, and prior stroke or transient ischemic attack (C-index = 0.65, 95% CI: 0.613–0.681), was developed. It was validated internally using a bootstrap method. In predicting 1-year survival for death alone, our 8-predictor model had an AUC of 0.63 (95% CI: 0.579–0.678) while the 14-predictor Seattle model had an AUC of 0.72. The Seattle model did not report stroke.

Conclusions

This novel prognostic model predicts the overall risk of ischemic stroke or death for HF patients. This model compares favorably for death with the Seattle model and has the added utility of including stroke as an endpoint. Use of this model will help identify those patients in need of more intensive monitoring and therapy and may help identify appropriate populations for trials of new therapies.

Item Type: Article
DOI/Identification number: 10.1016/j.jjcc.2015.09.014
Uncontrolled keywords: Heart failure; Stroke; Mortality; Risk factors
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Christine Buckley
Date Deposited: 03 Mar 2017 12:54 UTC
Last Modified: 29 May 2019 18:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/60688 (The current URI for this page, for reference purposes)
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