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Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders

Castor, Katherine J., Metera, Kimberly L., Tefashe, Ushula M., Serpell, Christopher J., Mauzeroll, Janine, Sleiman, Hanadi F. (2015) Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders. Inorganic Chemistry, 54 (14). pp. 6958-6967. ISSN 0020-1669. (doi:10.1021/acs.inorgchem.5b00921) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:60010)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://doi.org/10.1021/acs.inorgchem.5b00921

Abstract

Six cyclometalated iridium(III) phenanthroimidazole complexes with different modifications to the imidazole phenanthroline ligand exhibit enhanced luminescence when bound to guanine (G-) quadruplex DNA sequences. The complexes bind with low micromolar affinity to human telomeric and c-myc sequences in a 1:1 complex:quadruplex stoichiometry. Due to the luminescence enhancement upon binding to G-quadruplex DNA, the complexes can be used as selective quadruplex indicators. In addition, the electrogenerated chemiluminescence of all complexes increases in the presence of specific G-quadruplex sequences, demonstrating potential for the development of an ECL-based G-quadruplex assay.

Item Type: Article
DOI/Identification number: 10.1021/acs.inorgchem.5b00921
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 23 Jan 2017 10:41 UTC
Last Modified: 23 Jan 2020 04:12 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/60010 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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