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Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview

Chan, Queenie, Loo, Ruey Leng, Ebbels, Timothy, van horn, linda, Daviglus, Martha L., Stamler, Jeremiah, Nicholson, Jeremy K., Holmes, Elaine, Elliott, Paul (2017) Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview. Hypertension Research, 40 . pp. 336-345. ISSN 0916-9636. E-ISSN 1348-4214. (doi:10.1038/hr.2016.164)

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http://dx.doi.org/10.1038/hr.2016.164

Abstract

The etiopathogenesis of cardiovascular diseases (CVDs) is multifactorial. Adverse blood pressure (BP) is a major independent risk factor for epidemic CVD affecting ~40% of the adult population worldwide and resulting in significant morbidity and mortality. Metabolic phenotyping of biological fluids has proven its application in characterizing low-molecular-weight metabolites providing novel insights into gene-environmental-gut microbiome interaction in relation to a disease state. In this review, we synthesize key results from the INTERnational study of MAcro/micronutrients and blood Pressure (INTERMAP) Study, a cross-sectional epidemiologic study of 4680 men and women aged 40-59 years from Japan, the People's Republic of China, the United Kingdom and the United States. We describe the advancements we have made regarding the following: (1) analytical techniques for high-throughput metabolic phenotyping; (2) statistical analyses for biomarker identification; (3) discovery of unique food-specific biomarkers; and (4) application of metabolome-wide association studies to gain a better understanding into the molecular mechanisms of cross-cultural and regional BP differences.

Item Type: Article
DOI/Identification number: 10.1038/hr.2016.164
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Rueyleng Loo
Date Deposited: 12 Jan 2017 13:31 UTC
Last Modified: 29 May 2019 18:32 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/59847 (The current URI for this page, for reference purposes)
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