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Human Basophils are Differentially Activated by and are a Source of IL-31

Raap, U, Gehring, M, Kleiner, S, Rüdrich, U, Eiz-Vesper, B, Haas, Helmut, Kapp, A, Gibbs, Bernhard F (2017) Human Basophils are Differentially Activated by and are a Source of IL-31. Clinical and Experimental Allergy, 47 (4). pp. 499-508. ISSN 0954-7894. E-ISSN 1365-2222. (doi:10.1111/cea.12875) (KAR id:59776)

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Basophils are important effector cells involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is associated by increased IL-31 serum levels. So far the effects of IL-31 on human basophils are unknown.


IL-31 expression was evaluated in skin samples derived from chronic spontaneous urticaria patients. Oncostatin M receptor (OSMR), IL-31 receptor A (RA) and IL-31 protein expressions were analysed on human basophils from healthy donors. Basophil responses to IL-31 were assessed for chemotaxis, externalization of CD63 and CD203c as well as the release of histamine, IL-4 and IL-13.

Conclusions and Clinical Relevance

Human basophils are a source of –and are activated by – IL-31 with the release of pro-inflammatory cytokines and the induction of chemotaxis indicating an important novel function of IL-31 in basophil biology.

Item Type: Article
DOI/Identification number: 10.1111/cea.12875
Uncontrolled keywords: Basophils, Il-31, allergy
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RL Dermatology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 04 Jan 2017 14:12 UTC
Last Modified: 29 May 2019 18:30 UTC
Resource URI: (The current URI for this page, for reference purposes)
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