Skip to main content

Somatosensory attention identifies both overt and covert awareness in disorders of consciousness

Gibson, R. M., Chennu, S., Fernandez-Espejo, D., Naci, L., Owen, A. M., Cruse, D. (2016) Somatosensory attention identifies both overt and covert awareness in disorders of consciousness. Annals of Neurology, 80 (3). pp. 412-423. ISSN 0364-5134. E-ISSN 1531-8249. (doi:10.1002/ana.24726)

PDF - Author's Accepted Manuscript
Download (2MB) Preview
[img]
Preview
Official URL
http://dx.doi.org/10.1002/ana.24726

Abstract

Objective

Some patients diagnosed with disorders of consciousness retain sensory and cognitive abilities beyond those apparent from their overt behavior. Characterizing these covert abilities is crucial for diagnosis, prognosis, and medical ethics. This multimodal study investigates the relationship between electroencephalographic evidence for perceptual/cognitive preservation and both overt and covert markers of awareness.

Results

Six patients produced only sensory responses, with no evidence of cognitive event-related potentials. A further 8 patients demonstrated reliable bottom-up attention-orienting responses (P3a). No patient showed evidence of top-down attention (P3b). Only those patients who followed commands, whether overtly with behavior or covertly with functional neuroimaging, also demonstrated event-related potential evidence of attentional orienting.

Somatosensory attention-orienting event-related potentials differentiated patients who could follow commands from those who could not. Crucially, this differentiation was irrespective of whether command following was evident through overt external behavior, or through covert functional neuroimaging methods. Bedside electroencephalographic methods may corroborate more expensive and challenging methods such as functional neuroimaging, and thereby assist in the accurate diagnosis of awareness.

Item Type: Article
DOI/Identification number: 10.1002/ana.24726
Subjects: Q Science
Divisions: Faculties > Sciences > School of Computing
Depositing User: S. Chennu
Date Deposited: 18 Nov 2016 14:04 UTC
Last Modified: 24 Jan 2020 04:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/58786 (The current URI for this page, for reference purposes)
Chennu, S.: https://orcid.org/0000-0002-6840-2941
  • Depositors only (login required):

Downloads

Downloads per month over past year