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Cellular redox homeostasis, reactive oxygen species and replicative ageing inSaccharomyces cerevisiae

Ayer, Anita, Gourlay, Campbell W., Dawes, Ian W. (2014) Cellular redox homeostasis, reactive oxygen species and replicative ageing inSaccharomyces cerevisiae. FEMS Yeast Research, 14 (1). pp. 60-72. ISSN 1567-1356. (doi:10.1111/1567-1364.12114) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:58523)

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Ageing cells undergo changes in redox homeostasis and acquire high levels of reactive oxygen species (ROS). Because accumulation of ROS involves a change in redox state of cells, functions that are involved in setting redox and maintaining redox homeostasis are very relevant to an understanding of the possible roles of redox homeostasis and ROS in ageing. This review discusses these aspects of ROS in relation to replicative ageing in the model organism Saccharomyces cerevisiae, with reference to ROS generated in cells; cellular responses to oxidative stress; and how cells maintain redox homeostasis in different cellular compartments. It also considers when ROS generation begins as cells age, which ROS species are relevant to ageing and which cellular compartments and processes may contribute ROS to the ageing process. The discussion also covers the heterogeneity of cells with respect to ROS accumulation at particular cell ages, and the possibility of testing the oxidative theory of ageing in yeast cells.

Item Type: Article
DOI/Identification number: 10.1111/1567-1364.12114
Uncontrolled keywords: replicative ageing;redox homeostasis;reactive oxygen species
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Campbell Gourlay
Date Deposited: 10 Nov 2016 12:43 UTC
Last Modified: 06 Feb 2020 04:15 UTC
Resource URI: (The current URI for this page, for reference purposes)
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