Gonçalves Silva, Isabel, Rüegg, Laura, Gibbs, Bernhard F., Bardelli, Marco, Fruehwirth, Alexander, Varani, Luca, Berger, Steffen M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V. (2016) The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells. Oncoimmunology, 5 (7). ISSN 2162-4011. E-ISSN 2162-402X. (doi:10.1080/2162402X.2016.1195535) (KAR id:58345)
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Official URL: http://dx.doi.org/10.1080/2162402X.2016.1195535 |
Abstract
The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor. Recently, it has been demonstrated that Tim-3 forms an autocrine loop with its natural ligand galectin-9 in human AML cells. However, the pathophysiological functions of Tim-3 in human AML cells remain unclear. Here, we report for the first time that Tim-3 is required for galectin-9 secretion in human AML cells. However, this effect is cell-type specific and was found so far to be applicable only to myeloid (and not, for example, lymphoid) leukemia cells. We concluded that AML cells might use Tim-3 as a trafficker for the secretion of galectin-9 which can then be possibly used to impair the anticancer activities of cytotoxic T cells and natural killer (NK) cells.
Item Type: | Article |
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DOI/Identification number: | 10.1080/2162402X.2016.1195535 |
Uncontrolled keywords: | Acute myeloid leukemia; Tim-3; galectin-9, Medway School of Pharmacy |
Subjects: |
Q Science > QP Physiology (Living systems) > QP506 Molecular biology Q Science > QP Physiology (Living systems) > QP517 Biochemistry Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Bernhard F. Gibbs |
Date Deposited: | 02 Nov 2016 17:04 UTC |
Last Modified: | 09 Dec 2022 07:59 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/58345 (The current URI for this page, for reference purposes) |
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