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The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells

Goncalves Silva, Isabel, Rüegg, Laura, Gibbs, Bernhard F, Bardelli, Marco, Fruehwirth, Alexander, Varani, Luca, Berger, Steffen, Fasler-Kan, Elizaveta, Sumbayev, Vadim V. (2016) The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells. Oncoimmunology, 5 (7). e1195535. ISSN 2162-4011. E-ISSN 2162-402X. (doi:10.1080/2162402X.2016.1195535)

Abstract

The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor. Recently, it has been demonstrated that Tim-3 forms an autocrine loop with its natural ligand galectin-9 in human AML cells. However, the pathophysiological functions of Tim-3 in human AML cells remain unclear. Here, we report for the first time that Tim-3 is required for galectin-9 secretion in human AML cells. However, this effect is cell-type specific and was found so far to be applicable only to myeloid (and not, for example, lymphoid) leukemia cells. We concluded that AML cells might use Tim-3 as a trafficker for the secretion of galectin-9 which can then be possibly used to impair the anticancer activities of cytotoxic T cells and natural killer (NK) cells.

Item Type: Article
DOI/Identification number: 10.1080/2162402X.2016.1195535
Uncontrolled keywords: Acute myeloid leukemia; Tim-3; galectin-9
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 02 Nov 2016 17:04 UTC
Last Modified: 29 May 2019 18:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/58345 (The current URI for this page, for reference purposes)
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