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Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells

Sumbayev, Vadim V., Silva, Isabel Gonçalves, Blackburn, Jennifer, Gibbs, Bernhard F, Yasinska, Inna M., Garrett, Michelle D., Tonevitsky, Alexandre G., Ushkaryov, Yuri (2016) Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells. Oncotarget, 7 . pp. 45575-45583. E-ISSN 1949-2553. (doi:10.18632/oncotarget.10039) (KAR id:58343)

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http://dx.doi.org/10.18632/oncotarget.10039

Abstract

Acute myeloid leukaemia (AML) is a blood cancer affecting cells of myeloid lineage. It is characterised by rapid growth of malignant leukocytes that accumulate in the bone marrow and suppress normal haematopoiesis. This systemic disease remains a serious medical burden worldwide. Characterisation of protein antigens specifically expressed by malignant cells, but not by healthy leukocytes, is vital for the diagnostics and targeted treatment of AML. Here we report, for the first time, that the neuronal receptor latrophilin-1 is expressed in human monocytic leukaemia cell lines and in primary human AML cells. However, it is absent in healthy leukocytes. Latrophilin-1 is functional in leukaemia cells tested, and its biosynthesis is controlled through the mammalian target of rapamycin (mTOR), a master regulator of myeloid cell translational pathways. Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human AML, which offers potential new avenues for AML diagnosis and treatment.

Item Type: Article
DOI/Identification number: 10.18632/oncotarget.10039
Uncontrolled keywords: latrophilin; mammalian target of rapamycin; myeloid leukaemia, Medway school of pharmacy
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Michelle Garrett
Date Deposited: 02 Nov 2016 16:48 UTC
Last Modified: 06 May 2020 03:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/58343 (The current URI for this page, for reference purposes)
Sumbayev, Vadim V.: https://orcid.org/0000-0002-9404-5626
Garrett, Michelle D.: https://orcid.org/0000-0002-3939-1673
Ushkaryov, Yuri: https://orcid.org/0000-0002-5712-8297
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