Skip to main content

Controlling the Functionality of Block Copolymer Bicontinuous Nanospheres

Monaghan, Olivia Rose (2015) Controlling the Functionality of Block Copolymer Bicontinuous Nanospheres. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:57833)

Language: English
Download (14MB) Preview
[thumbnail of 26Olivia Rose Monaghan PHD Thesis Corrections-FINAL COPY SUBMITTED.pdf]
This file may not be suitable for users of assistive technology.
Request an accessible format


Amphiphilic block copolymers (BCPs) form self-assembled aggregates in solution with a range of morphologies including spherical micelles, cylindrical micelles, vesicles (polymersomes) and bicontinuous nanospheres. This research focuses on the formation of bicontinuous nanospheres using a number of different BCPs for use in thermo-responsive drug delivery.

To further demonstrate the control achieved over the Tm, random copolymers of ODMA and DSMA using a PEO macroinitiator were synthesised at varying wt % ratios of PODMA:PDSMA. DSC analysis of these polymers showed that an increase in PDSMA led to an increase in the Tm for the bulk and self-assembled samples. The controlled release of Ibuprofen from these bicontinuous nanospheres was investigated to determine the rate of release and the optimum temperature for release following a previously used method. The concentration of release was then analysed using HPLC.

To incorporate acid functionality into the bicontinuous nanospheres PMAA-b-PODMA (poly(methacrylic acid)-block-poly(octadecyl methacrylate)) was synthesised (via ATRP) with hydrophilic wt % of 20 %. The self-assembled solution of PMAA-b-PODMA was analysed using cryo-TEM which revealed the presence of bicontinuous nanospheres. Another approach to incorporate acid functionality into bicontinuous nanospheres was the self-assembled of PEO-b-PS and PEO-b-PODMA followed by the alkaline hydrolysis of PEO to leave an acid end group.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Holder, Simon
Uncontrolled keywords: Polymer Chemistry Self-Assembly Nanospheres Micelles Block Copolymers
Subjects: Q Science > QC Physics
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Users 1 not found.
Date Deposited: 10 Oct 2016 11:00 UTC
Last Modified: 16 Feb 2021 13:38 UTC
Resource URI: (The current URI for this page, for reference purposes)
  • Depositors only (login required):