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A Prototype Instrument for Simultaneous Indocyanine Green (ICG) Angiography and Multi–planar Optical Coherence Tomography(OCT) Imaging of the Retina

Rosen, Richard B., Dobre, George, Cernat, Ramona, Jackson, David A., Garcia, P.M.T., Muldoon, T., Ponce, W.A., Gentile, R.C., Podoleanu, Adrian G.H. (2004) A Prototype Instrument for Simultaneous Indocyanine Green (ICG) Angiography and Multi–planar Optical Coherence Tomography(OCT) Imaging of the Retina. Investigative Ophthalmology & Visual Science, 45 (13). p. 2396. ISSN 0146-0404. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:56078)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.

Abstract

Purpose: To describe preliminary results using a prototype instrument which can simultaneously acquire multi–planar OCT images and ICG angiographic studies of the fundus. Methods:The instrument employs a scanning interferometer configuration which produces paired C–scan planar OCT and confocal ophthalmoscopic images. The optical source, a superluminescent diode (SLD)?= 793 nm, is used for both OCT reflectometry and for the excitation of the ICG fluorescence. The system is also capable of providing OCT B–scans at selected points from the ICG confocal image. Subjects were studied pre and post injection of ICG dye into an antecubital vein. Special care was given to capture early transit phase images through the choroid and retina and corresponding late phase images for evidence of delayed fluorescence accumulations. OCT B–scan sequences were collected in response to observed areas of increased fluorescence seen in the confocal channel. Results:Images from 5 healthy eyes and 5 eyes with macular degeneration have been initially obtained. The vasculature is well defined in the confocal ICG image, while patchy and difficult to trace in the OCT image. At the same time, the depth resolution in the ICG channel is low (?1 mm) and anatomic relationships are flattened. The overlay feature of the viewing software allowed the precisely registered images to fuse, permitting accurate localization of fluorescence highlighted features in depth. Conclusions:The multi–planar C–scan OCT/ICG ophthalmoscope provides a unique integration of OCT morphologic and ICG angiographic functional imaging technologies. The pixel–to–pixel correspondence inherent in of this system allows accurate superimposition of the paired image channels which may better help elucidate some of the complex relationships between the 3–dimensional anatomy and the retinal and choroidal circulations.

Item Type: Article
Additional information: Unmapped bibliographic data: ST - A prototype instrument for simultaneous indocyanine green )ICG) angiography and multi-planar [Field not mapped to EPrints] AN - WOS:000223338002327 [Field not mapped to EPrints]
Uncontrolled keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound), imaging/image analysis: clinical, retina
Subjects: Q Science
Q Science > QC Physics
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: George Dobre
Date Deposited: 27 Jun 2016 08:52 UTC
Last Modified: 16 Nov 2021 10:23 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/56078 (The current URI for this page, for reference purposes)
Dobre, George: https://orcid.org/0000-0002-5695-2591
Podoleanu, Adrian G.H.: https://orcid.org/0000-0002-4899-9656
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