Factor XIIa and triacylglycerol rich lipoproteins: responses to exercise intervention

Woolf-May, Kate and Jones, David Wynne and Kearney, Edward M. and Davison, R.C. and Bird, Steve R. (2000) Factor XIIa and triacylglycerol rich lipoproteins: responses to exercise intervention. British Journal of Sports Medicine, 34 (4). pp. 289-292. ISSN 0306-3674 . (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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OBJECTIVES: (a) To determine if factor XIIa (FXIIa) would be sensitive to change from exercise intervention in a group of previously sedentary/low active middle aged men and women; (b) to investigate further the previously reported relation between FXIIa and triacylglycerol (TAG) rich lipoproteins. METHODS: Thirty seven men (mean (SD) age 57 (7) years) and 60 women (mean age 54 (7) years) completed the study. Before the intervention, these subjects were randomly allocated to a group of walkers (n = 81) or controls (n = 16). Before and after an 18 week walking intervention, fasted blood samples were collected and analysed for FXIIa, TAG, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and apolipoprotein (apo) B. RESULTS: Kruskal-Wallis analysis of data obtained before the intervention showed no significant differences (p>0.4) between the walking and control groups for age, height, body mass, gender, FXIIa, TAG, TC, HDL-C, or apo B, although the women did show significantly lower levels of TAG (p<0.04) and higher HDL-C (p<0.0001) than the men. General linear model analysis of data obtained after the intervention, using the baseline value as a covariate, showed significant reductions (p<0.0001) in FXIIa for the walkers compared with the controls. Pearson product-moment correlations also showed significant relations between the concentrations of FXIIa and TAG, TC, LDL-C, and apo B. CONCLUSIONS: The findings of this study suggest that FXIIa is sensitive to change from exercise intervention and support previous research showing an association between the concentrations of FXIIa and TAG rich lipoproteins.

Item Type: Article
Additional information: 0306-3674 (Print) Clinical Trial Journal Article Randomized Controlled Trial
Uncontrolled keywords: factor XIIa; Hageman factor; exercise; walking; lipoproteins; coronary heart disease
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: D.W. Jones
Date Deposited: 27 May 2009 07:13
Last Modified: 09 May 2014 10:38
Resource URI: https://kar.kent.ac.uk/id/eprint/5599 (The current URI for this page, for reference purposes)
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