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Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis

Dyer, J., Davison, Glen, Marcora, Samuele Maria, Mauger, Alexis R. (2017) Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis. The Journal of Nutrition, Health and Aging, 21 (5). pp. 562-566. ISSN 1279-7707. E-ISSN 1760-4788. (doi:10.1007/s12603-016-0806-y)

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Objectives: To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA). Participants: Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female). Setting: Southeast of England, UK. Design: Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet. Measurements: All participants completed an Arthritis Impact Measurement Scale (AIMS2) pre-, mid- and post- study period. A subset of participants attended a clinic at the start and end of the study for assessment of joint range of motion, ROM (DIET = 33, CON = 28), and to provide blood samples (DIET = 29, CON = 25) for biomarker analysis (including serum cartilage oligomeric matrix protein (sCOMP) (a marker of cartilage degradation) and a panel of other relevant biomarkers including pro- and anti-inflammatory cytokines). Results: There were no differences between groups in the response of any AIMS2 components and most biomarkers (p > 0.05), except the pro-inflammatory cytokine IL-1?, which decreased in the DIET group (~47%, p = 0.010). sCOMP decreased in the DIET group by 1 U/L (~8%, p = 0.014). There was a significant improvement in knee flexion and hip rotation ROM in the DIET group (p < 0.05). Conclusions: The average reduction in sCOMP in the DIET group (1 U/L) represents a meaningful change, but the longer term effects require further study.

Item Type: Article
DOI/Identification number: 10.1007/s12603-016-0806-y
Uncontrolled keywords: Diet; sCOMP; AIMS2; IL-1α; osteoarthritis (OA); Mediterranean diet
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Faculties > Sciences > School of Sport and Exercise Sciences
Depositing User: Lex Mauger
Date Deposited: 31 May 2016 13:49 UTC
Last Modified: 23 Jan 2020 04:11 UTC
Resource URI: (The current URI for this page, for reference purposes)
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