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Incidence, Sex Ratio and Perinatal Outcomes of IVF and ICSI Monozygotic Twin Pregnancies Following either Cleavage or Blastocyst Stage Embryo Transfer

Al Dibouni, Z., Shah, Tina, Wheat, S., Griffin, Darren K., Thornhill, Alan R. (2016) Incidence, Sex Ratio and Perinatal Outcomes of IVF and ICSI Monozygotic Twin Pregnancies Following either Cleavage or Blastocyst Stage Embryo Transfer. Human Genetics & Embryology, 6 (1). ISSN 2161-0436. (doi:10.4172/2161-0436.1000132) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:55711)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://www.dx.doi.org/10.4172/2161-0436.1000132

Abstract

To determine if prolonged time in embryo culture has an effect on the rate, sex ratio, and perinatal outcomes of monozygotic twins (MZT) following either cleavage stage or blastocyst embryo transfer after assisted conception. This is a retrospective study of 2,316 consecutive clinical pregnancies resulting from cleavage stage transfer (CT) and blastocyst transfer (BT). Criteria examined included (i) incidences (ii) sex ratios (iii) gestational age and birth weight; (iv) perinatal outcomes of these pregnancies from cleavage stage and blastocyst transfer procedures. Monozygotic twin pregnancies were identified by (i) presence of a gestational sac containing more than one fetal pole with cardiac activity, (ii) the number of gestational sacs or fetal hearts exceeds the number of embryos transferred and (iii) twin pregnancies following a single embryo transfer. Overall the incidence of twinning was 1.64% (38 out of 2,316 pregnancies). The frequency of twinning was 2.3 × higher following BT (18 out of 649) compared to CT (20 out of 1,667). IVF techniques skewed the sex ratio in favour of males while ICSI significantly favoured females. There was no statistically significant difference between transfer type and gestational age, birth weight and perinatal outcome. All pregnancies resulted in the birth of 86 infants. In our experience, BT more than doubles the chances of conceiving a monozygotic twin pregnancy, however IVF techniques lead to a greater likelihood of male birth(s) if twins are conceived. Appropriate pre-conception counselling should be given to advise the potential risks associated with both types of transfer as well as using alternative methods such as single embryo transfer to reduce the risk of multiple gestations.

Item Type: Article
DOI/Identification number: 10.4172/2161-0436.1000132
Uncontrolled keywords: Blastocyst; Cleavage; IVF/ICSI; Monozygotic twinning; Perinatal outcomes
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 26 May 2016 15:17 UTC
Last Modified: 17 Aug 2022 12:20 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/55711 (The current URI for this page, for reference purposes)

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