Smith, Jennifer R., Moreno, Lucas, Heaton, Simon P., Chesler, Louis, Pearson, Andrew D.J., Garrett, Michelle D. (2016) Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastoma. Molecular Oncology, 10 (4). pp. 538-552. ISSN 1574-7891. (doi:10.1016/j.molonc.2015.11.005) (KAR id:55391)
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Official URL http://doi.org/10.1016/j.molonc.2015.11.005 |
Abstract
There is an urgent need for improved therapies for children with high-risk neuroblastoma
associated with aggressive neuroblastoma and drugs targeting PI3K/AKT/mTOR, to activate
validate pharmacodynamic (PD) biomarkers to evaluate both proof of mechanism and proof
Wehave addressed the issue of limited access to tumor biopsies for quantitative detection
(FACS) method to purify CD45?/GD2+/CD56+ neuroblastoma cells from bone marrow. We
cells, providing the potential to demonstrate proof of concept for drugs that inhibit
detection of three biomarkers for AKT pathway activity (phosphorylated and total AKT,
ournewapproachto neuroblastomacell isolation for protein detection and suite ofPD assays
PD biomarkers in this pediatric patient population. These will be ideal tools to support
in upcoming clinical trials in neuroblastoma.
Item Type: | Article |
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DOI/Identification number: | 10.1016/j.molonc.2015.11.005 |
Uncontrolled keywords: | Neuroblastoma; MYCN; AKT; Pharmacodynamic; Biomarker |
Subjects: | Q Science |
Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
Depositing User: | Michelle Garrett |
Date Deposited: | 11 May 2016 15:02 UTC |
Last Modified: | 27 Jan 2021 15:08 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/55391 (The current URI for this page, for reference purposes) |
Garrett, Michelle D.: | ![]() |
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