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A cluster randomised control trial to evaluate the effectiveness and cost-effectiveness of the Italian Medicines Use Review (I-MUR) for asthma patients Background

Manfrin, Andrea (2016) A cluster randomised control trial to evaluate the effectiveness and cost-effectiveness of the Italian Medicines Use Review (I-MUR) for asthma patients Background. BMCSeriesEditorial None. Located at: KAR. (Unpublished) (KAR id:54941)

Microsoft Excel (Data set used for the intention to treat analysis of the CRCT I-MUR) Author's Accepted Manuscript
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Abstract

The economic burden of asthma, which relates to the degree of control, is €5 billion annually in Italy. Pharmacists could help improve asthma control, reducing this burden.

Methods

Intervention Systematic, structured face-to-face consultation with a pharmacist, covering asthma symptoms, medicines used, attitude towards medicines and adherence, recording pharmacist-identified pharmaceutical care issues (PCIs).

Blinding was not possible for either pharmacists or patients. Assessment of outcomes was conducted by researchers blind to group allocation.

Results Numbers of pharmacists and patients enrolled were 283 (A=136; B=147) and 1263 (A=600; B=663), numbers completing were 201 (A=97; B=104) and 816 (A=400; B=416), respectively. Patients were similar in age and gender and 56.13% (458/816) had poor/partial asthma control. Median ACT score at baseline differed between groups (A=19, B=18; p<0.01). Odds ratio for improved asthma control was 1.76 (95% CI 1.33 to 2.33) and number needed to treat 10 (95% CI 6 to 28). Number of active ingredients reduced by 7.9% post-intervention (p<0.01). Adherence improved by 35.4% three months post-intervention and 40.0% at six months (p<0.01). Pharmacists identified 1256 PCIs (mean 1.54/patient), mostly need for education, monitoring and potentially ineffective therapy. The probability of the intervention being more cost-effective than usual care was 100% at nine months.

TRN: ISRCTN72438848 (registered 5th January 2015)

Item Type: Datasets / databases
Projects: [UNSPECIFIED] Randomised evaluation of the Italian Medicine Use Review Provided by community pharmacists using asthma as a model (RE I-MUR)
Uncontrolled keywords: Data used for the intention to treat analysis in the I-MUR study
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Andrea Manfrin
Date Deposited: 13 Apr 2016 11:55 UTC
Last Modified: 25 May 2021 15:23 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/54941 (The current URI for this page, for reference purposes)
Manfrin, Andrea: https://orcid.org/0000-0003-3457-9981
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