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Relationship between aetiology and covert cognition in the minimally-conscious state

Cruse, Damian, Chennu, Srivas, Chatelle, Camille, Fernández-Espejo, Davinia, Bekinschtein, Tristan A., Pickard, John D., Laureys, Steven, Owen, Adrian M. (2012) Relationship between aetiology and covert cognition in the minimally-conscious state. Neurology, 78 (11). pp. 816-822. ISSN 0028-3878. E-ISSN 1526-632X. (doi:10.1212/WNL.0b013e318249f764) (KAR id:54644)

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Abstract

Objectives: Functional neuroimaging has shown that the absence of externally observable signs of consciousness and cognition in severely brain-injured patients does not necessarily indicate the true absence of such abilities. However, relative to traumatic brain injury, nontraumatic injury is known to be associated with a reduced likelihood of regaining overtly measurable levels of consciousness. We investigated the relationships between etiology and both overt and covert cognitive abilities in a group of patients in the minimally conscious state (MCS).

Results: Consistent and robust responses to command were observed in the EEG of 22% of the MCS patients (5 of 23). Etiology had a significant impact on the ability to successfully complete this task, with 33% of traumatic patients (5 of 15) returning positive EEG outcomes compared with none of the nontraumatic patients (0 of 8).

Conclusions: The overt behavioral signs of awareness (measured with the Coma Recovery Scale–Revised) exhibited by nontraumatic MCS patients appear to be an accurate reflection of their covert cognitive abilities. In contrast, one-third of a group of traumatically injured patients in the MCS possess a range of high-level cognitive faculties that are not evident from their overt behavior.

Item Type: Article
DOI/Identification number: 10.1212/WNL.0b013e318249f764
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculties > Sciences > School of Computing
Depositing User: Srivas Chennu
Date Deposited: 13 Apr 2016 09:32 UTC
Last Modified: 24 Jan 2020 04:08 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/54644 (The current URI for this page, for reference purposes)
Chennu, Srivas: https://orcid.org/0000-0002-6840-2941
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