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Brain Connectivity Dissociates Responsiveness from Drug Exposure during Propofol-Induced Transitions of Consciousness

Chennu, Srivas, O’Connor, Stuart, Adapa, Ram, Menon, David K., Bekinschtein, Tristan A. (2016) Brain Connectivity Dissociates Responsiveness from Drug Exposure during Propofol-Induced Transitions of Consciousness. PLoS Computational Biology, 12 (1). pp. 1-17. ISSN 1553-734X. E-ISSN 1553-7358. (doi:10.1371/journal.pcbi.1004669) (KAR id:54628)

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Accurately measuring the neural correlates of consciousness is a grand challenge for neuroscience. Despite theoretical advances, developing reliable brain measures to track the loss of reportable consciousness during sedation is hampered by significant individual variability in susceptibility to anaesthetics. We addressed this challenge using high-density electroencephalography to characterise changes in brain networks during propofol sedation. Assessments of spectral connectivity networks before, during and after sedation were combined with measurements of behavioural responsiveness and drug concentrations in blood. Strikingly, we found that participants who had weaker alpha band networks at baseline were more likely to become unresponsive during sedation, despite registering similar levels of drug in blood. In contrast, phase-amplitude coupling between slow and alpha oscillations correlated with drug concentrations in blood. Our findings highlight novel markers that prognosticate individual differences in susceptibility to propofol and track drug exposure. These advances could inform accurate drug titration and brain state monitoring during anaesthesia.

Item Type: Article
DOI/Identification number: 10.1371/journal.pcbi.1004669
Subjects: Q Science > QA Mathematics (inc Computing science)
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Srivas Chennu
Date Deposited: 13 Apr 2016 09:49 UTC
Last Modified: 16 Feb 2021 13:33 UTC
Resource URI: (The current URI for this page, for reference purposes)
Chennu, Srivas:
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