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The mechanisms of latrophilin 1-mediated control of spontaneous exocytosis at the mouse neuromuscular junction

Petitto, Evelina (2015) The mechanisms of latrophilin 1-mediated control of spontaneous exocytosis at the mouse neuromuscular junction. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:54354)

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Abstract

Latrophilin1 (LPHN1) is a presynaptic adhesion G protein-coupled receptor involved in the control of spontaneous exocytosis of neurotransmitters. The effects of LPHN1 activation on exocytosis have been described on several model systems, such as cultured hippocampal neurons and neuromuscular junction (NMJ) using its well known agonist LTXN4C, and include a massive increase in exocytosis characterised by periods of intense release (bursts) interspersed with periods of moderate activity (interburst intervals).

Altogether, this work uncovered the mechanisms by which G protein-coupled receptors, in this case LPHN1, can regulate the rate of spontaneous neurotransmitter release at the mouse NMJ.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Ushkaryov, Yuri
Uncontrolled keywords: Spontaneous exocytosis; G protein-coupled receptors; latrophilin; neuroscience
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Users 1 not found.
Date Deposited: 29 Feb 2016 14:37 UTC
Last Modified: 16 Feb 2021 13:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/54354 (The current URI for this page, for reference purposes)
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