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Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles

Edwardson, Thomas G. W., Lau, Kai Lin, Bousmail, Danny, Serpell, Christopher J., Sleiman, Hanadi F. (2016) Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles. Nature Chemistry, 8 (2). pp. 162-170. ISSN 1755-4330. E-ISSN 1755-4349. (doi:10.1038/NCHEM.2420)

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http://dx.doi.org/10.1038/NCHEM.2420

Abstract

DNA nanotechnology offers unparalleled precision and programmability for the bottom-up organization of materials. This approach relies on pre-assembling a DNA scaffold, typically containing hundreds of different strands, and using it to position functional components. A particularly attractive strategy is to employ DNA nanostructures not as permanent

We show that the particles inherit the DNA sequence configuration encoded in the parent template with high fidelity. This provides control over the number of DNA strands and their relative placement, directionality and sequence asymmetry. Importantly, the nanoparticles produced exhibit the site-specific addressability of DNA nanostructures, and are promising components for energy, information and biomedical applications.

Item Type: Article
DOI/Identification number: 10.1038/NCHEM.2420
Uncontrolled keywords: Nanoparticles; Organizing materials with DNA; Surface assembly, Functional Materials Group
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Christopher Serpell
Date Deposited: 01 Mar 2016 14:36 UTC
Last Modified: 10 Feb 2020 16:20 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/53832 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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