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Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney.

Wildman, Scott S.P., Dunn, Kadeshia, Peppiatt-Wildman, Claire M., Kelley, Stephen P. (2014) Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. Journal of Nephrology and Urology Research, 2 (2). pp. 47-57. ISSN 2310-984X. (doi:10.12970/2310-984X.2014.02.02.5)

Abstract

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects. In addition to its role in the CNS, an increasing number of publications have suggested that GABA might also play a role in the regulation of renal function. All three enzymes associated with GABA metabolism; glutamic acid decarboxylase, GABA ?-oxoglutarate transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH) have been localised to the kidney providing the necessary machinery for localised GABA synthesis and metabolism. Moreover GABA receptors have been localised to both tubular and vascular structures in the kidney, and GABA is excreted in urine (~3 ?M) in humans. Despite the collective evidence describing the presence of a GABA system in the kidney, the precise function of such a system requires further clarification. Here we provide an overview of the current renal GABA literature and provide novel data that indicates GABA can act at contractile pericyte cells located along vasa recta capillaries in the renal medulla to potentially regulate medullary blood flow.

Item Type: Article
DOI/Identification number: 10.12970/2310-984X.2014.02.02.5
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Scott S.P. Wildman
Date Deposited: 10 Dec 2015 17:39 UTC
Last Modified: 06 Feb 2020 04:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/53107 (The current URI for this page, for reference purposes)
Peppiatt-Wildman, Claire M.: https://orcid.org/0000-0002-4406-8571
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