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Dissecting signaling and functions of adhesion G protein-coupled receptors.

Araç, Demet, Aust, Gabriela, Calebiro, Davide, Engel, Felix B, Formstone, Caroline, Goffinet, André, Hamann, Jörg, Kittel, Robert J, Liebscher, Ines, Lin, Hsi-Hsien, and others. (2012) Dissecting signaling and functions of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences, 1276 . pp. 1-25. ISSN 1749-6632. (doi:10.1111/j.1749-6632.2012.06820.x) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

Abstract

G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, ?-subunit) and C-terminal fragment (CTF, CT, ?-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.

Item Type: Article
DOI/Identification number: 10.1111/j.1749-6632.2012.06820.x
Subjects: Q Science > QH Natural history > QH581.2 Cell Biology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Yuri Ushkaryov
Date Deposited: 10 Dec 2015 17:43 UTC
Last Modified: 29 May 2019 16:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/53106 (The current URI for this page, for reference purposes)
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