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Emerging key roles for P2X receptors in the kidney

Birch, R. E., Schwiebert, E. M., Peppiatt-Wildman, Claire M., Wildman, Scott S.P. (2013) Emerging key roles for P2X receptors in the kidney. Frontiers in Physiology, 4 . pp. 1-8. ISSN 1664-042X. (doi:10.3389/fphys.2013.00262)

Abstract

P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature describing a regulatory role of P2 receptors (P2R) in the kidney, there are significantly less data on the regulatory role of P2X receptors (P2XR) compared with that described for metabotropic P2Y. Much of the historical literature describing a role for P2XR in the kidney has focused heavily on the role of P2X1R in the autoregulation of renal blood flow. More recently, however, there has been a plethora of manuscripts providing compelling evidence for additional roles for P2XR in both kidney health and disease. This review summarizes the current evidence for the involvement of P2XR in the regulation of renal tubular and vascular function, and highlights the novel data describing their putative roles in regulating physiological and pathophysiological processes in the kidney.

Item Type: Article
DOI/Identification number: 10.3389/fphys.2013.00262
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Scott S.P. Wildman
Date Deposited: 10 Dec 2015 16:34 UTC
Last Modified: 29 May 2019 16:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/53088 (The current URI for this page, for reference purposes)
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