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P2X receptors: epithelial ion channels and regulators of salt and water transport.

Wildman, Scott S.P., King, Brian F. (2008) P2X receptors: epithelial ion channels and regulators of salt and water transport. Nephron Physiology, 108 (3). p60-67. ISSN 1660-8151. E-ISSN 1660-2137. (doi:10.1159/000122028) (KAR id:53053)

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When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion channels, P2X receptors, play a specialized role in the regulation of ion and water movement across the renal tubule and are integral to electrolyte and fluid homeostasis. In this short review, we discuss the concept of P2X receptors as regulators of salt and water salvage pathways, as well as acknowledging their accepted role as ATP-gated ion channels.

Item Type: Article
DOI/Identification number: 10.1159/000122028
Uncontrolled keywords: P2X Receptor; Ligand-gated ion channel; Nucleotide; Adenosine 5'-triphosphate; Epithelial cells, renal; ATP; P2Y
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Scott S.P. Wildman
Date Deposited: 10 Dec 2015 14:42 UTC
Last Modified: 16 Feb 2021 13:31 UTC
Resource URI: (The current URI for this page, for reference purposes)
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