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The Blastocystis mitochondrion-like organelles

Tsaousis, Anastasios D. and Stechmann, Alexandra and Pérez-Brocal, Vicente and Hamblin, Karleigh A. and van der Giezen, Mark and Clark, C. Graham (2010) The Blastocystis mitochondrion-like organelles. In: Clark, C. Graham and Adam, Rodney D. and Johnson, Patricia, eds. Anaerobic Parasitic Protozoa: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-61-5. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
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Abstract

The organelles in Blastocystis that resemble mitochondria are an enigma as the organism is a strict anaerobe. Recent sequence analyses of the organelle genome and over 12,000 expressed sequence tags (ESTs) has given us many insights into the role these organelles play in the metabolism of the cell. The genome encodes several subunits of NADH dehydrogenase (complex I) but lacks all trace of genes for cytochrome and ATPase subunits (Complexes III-V). ESTs confirm the presence of complexes I and II, and indicate that this partial electron transport chain may lead to an alternative oxidase. The ESTs also suggest that many other metabolic pathways characteristic of mitochondria are still present in the Blastocystis organelles. However, other findings show that the organelle also has characteristics in common with hydrogenosomes, as a gene encoding [FeFe] hydrogenase is present and the protein has been localised to the organelles. The nuclear genome should clarify many of the remaining questions surrounding these unusual organelles.

Item Type: Book section
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Anastasios Tsaousis
Date Deposited: 08 Dec 2015 13:01 UTC
Last Modified: 29 May 2019 16:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/52920 (The current URI for this page, for reference purposes)
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