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Do acute elevations of serum creatinine in primary care engender an increased mortality risk?

Hobbs, Helen, Bassett, Paul, Wheeler, Toby, Bedford, Michael, Irving, Jean, Stevens, Paul E., Farmer, Christopher K. (2014) Do acute elevations of serum creatinine in primary care engender an increased mortality risk? BMC Nephrology, 15 (206). ISSN 1471-2369. E-ISSN 1471-2369. (doi:10.1186/1471-2369-15-206)

Abstract

Background: The significant impact Acute Kidney Injury (AKI) has on patient morbidity and mortality emphasizes

widely studied but little is known about the incidence and outcomes of patients experiencing acute elevations in

study was to define this incidence and explore its impact on mortality.

Methods: The study cohort was identified by using hospital data bases over a six month period.

Inclusion criteria: People with a serum creatinine request during the study period, 18 or over and not on renal

The patients were stratified by a rise in serum creatinine corresponding to the Acute Kidney Injury Network (AKIN)

Ethical approval was granted from National Research Ethics Service (NRES) Committee South East Coast and from the

acute serum creatinine rises overall were, ‘AKI 1’ 3,798 (72), ‘AKI 2’ 232 (73), and ‘AKI 3’ 102 (68) which equates to an

to 98.6%, 90.1% and 82.3% in those with ‘AKI 1’, ‘AKI 2’ and ‘AKI 3’ respectively. After multivariable analysis adjusting for

(95% CI 21.6, 62.7) and 123 (95% CI 64.8, 235) respectively, compared to those without acute serum creatinine rises as

hospital have significantly worse outcomes than those with stable kidney function.

Item Type: Article
DOI/Identification number: 10.1186/1471-2369-15-206
Uncontrolled keywords: AKI, Primary care, Mortality and epidemiology
Subjects: R Medicine > RC Internal medicine
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Chris Farmer
Date Deposited: 08 Dec 2015 12:24 UTC
Last Modified: 06 Feb 2020 04:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/52918 (The current URI for this page, for reference purposes)
Farmer, Christopher K.: https://orcid.org/0000-0003-1736-8242
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