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Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS

Romei, Vincenzo, Bauer, Markus, Brooks, Joseph L, Economides, Marcos, Penny, Will, Thut, Gregor, Driver, Jon, Bestmann, Sven (2016) Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS. Neuroimage, 126 . pp. 120-130. ISSN 1053-8119. (doi:10.1016/j.neuroimage.2015.11.020)

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Abstract

Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic rhythmicity remain unclear. Here, we show that sensorimotor cortex precisely follows externally applied rhythmic TMS (rTMS) stimulation in the beta-band but that the elicited responses are strongest at the intrinsic individual beta-peak-frequency. While these entrainment effects are of short duration, even subthreshold rTMS pulses propagate through the network and elicit significant cortico-spinal coupling, particularly when stimulated at the individual beta-frequency. Our results show that externally enforced rhythmicity interacts with intrinsic brain rhythms such that the individual peak frequency determines the effect of rTMS. The observed downstream spinal effect at the resonance frequency provides evidence for the causal role of brain rhythms for signal propagation.

Item Type: Article
DOI/Identification number: 10.1016/j.neuroimage.2015.11.020
Additional information: Full text upload complies with journal regulations
Uncontrolled keywords: TMS; motor cortex; beta rhythm
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science
Divisions: Faculties > Social Sciences > School of Psychology
Faculties > Social Sciences > School of Psychology > Cognitive Psychology
Faculties > University wide - Teaching/Research Groups > Centre for Cognitive Neuroscience and Cognitive Systems
Depositing User: J. Brooks
Date Deposited: 10 Nov 2015 09:25 UTC
Last Modified: 29 May 2019 16:19 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/51620 (The current URI for this page, for reference purposes)
Brooks, Joseph L: https://orcid.org/0000-0002-5364-3611
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