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Thermal Fluctuations of Red Blood Cell Membrane via a Constant-Area Particle-Dynamics Model

Marcelli, Gianluca, Parker, Kim H., Winlove, C. Peter (2005) Thermal Fluctuations of Red Blood Cell Membrane via a Constant-Area Particle-Dynamics Model. Biophysical Journal, 89 (4). pp. 2473-2480. ISSN 0006-3495. (doi:10.1529/biophysj.104.056168) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://doi.org/10.1529/biophysj.104.056168

Abstract

We describe a model of the mechanical properties of the cell plasma membrane using a finite-temperature particle-dynamics simulation of the whole cell, in which a two-dimensional network of virtual particles embedded in a three-dimensional closed surface represents the membrane. The particles interact via harmonic potential and dihedral angle potential and are subject to a constant area constraint. The evolution of the positions of the particles yields the equilibrium state of the membrane and allows determination of the membrane thermal fluctuations and the elastic moduli. We show that time-averaging of the cell-model configurations allows quantitative comparison with experimental data on membrane fluctuations and elastic moduli of the red blood cell.

Item Type: Article
DOI/Identification number: 10.1529/biophysj.104.056168
Subjects: T Technology
Divisions: Faculties > Sciences > School of Engineering and Digital Arts > Instrumentation, Control and Embedded Systems
Depositing User: Tina Thompson
Date Deposited: 09 Nov 2015 11:49 UTC
Last Modified: 29 May 2019 16:18 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/51556 (The current URI for this page, for reference purposes)
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