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Chaxapeptin, a Lasso Peptide from ExtremotolerantStreptomyces leeuwenhoekiiStrain C58 from the Hyperarid Atacama Desert.

Elsayed, Somayah S., Trusch, Franziska, Deng, Hai, Raab, Andrea, Prokes, Ivan, Busarakam, Kanungnid, Asenjo, Juan A., Andrews, Barbara A., van West, Pieter, Bull, Alan T., and others. (2015) Chaxapeptin, a Lasso Peptide from ExtremotolerantStreptomyces leeuwenhoekiiStrain C58 from the Hyperarid Atacama Desert. The Journal of Organic Chemistry, 80 (20). pp. 10252-10260. ISSN 0022-3263. (doi:10.1021/acs.joc.5b01878) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://doi.org/10.1021/acs.joc.5b01878

Abstract

Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that possess a unique “lariat knot” structural motif. Genome mining-targeted discovery of new natural products from microbes obtained from extreme environments has led to the identification of a gene cluster directing the biosynthesis of a new lasso peptide, designated as chaxapeptin 1, in the genome of Streptomyces leeuwenhoekii strain C58 isolated from the Atacama Desert. Subsequently, 1 was isolated and characterized using high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance methods. The lasso nature of 1 was confirmed by calculating its nuclear Overhauser effect restraint-based solution structure. Chaxapeptin 1 displayed a significant inhibitory activity in a cell invasion assay with human lung cancer cell line A549.

Item Type: Article
DOI/Identification number: 10.1021/acs.joc.5b01878
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 22 Oct 2015 10:59 UTC
Last Modified: 01 Aug 2019 10:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/51195 (The current URI for this page, for reference purposes)
Bull, Alan T.: https://orcid.org/0000-0001-6223-7722
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