Initial analysis of drug-induced heterogeneity in cancer cell lines

Drug-induced heterogeneity of cancer cells is a known concept that is not well understood.

same tumour can show distinct morphologies and genetic phenotypes, due to an increased

thought to be a diver of heterogeneity leading to acquired-drug resistance. This is when a

in treatment failure, leading to loss of life of the patient if no other treatments are available.

due to the need for multiple and extensive biopsies of the patient’s cancer. Therefore the

experimental investigations into model cell lines.

lines, with the aim of creating a protocol that allows comparison between different cell lines

cell lines with the hope of later identifying cross-resistance with other drugs. Moreover,

and exposing them to a number of tubulin-binding drugs, with the aim of making

number of drugs.

heterogenic sub-lines. We also concluded that exposure of cells to drugs of a similar

mechanism of action can lead to varying results.