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Development of microwave synthetic routes to silica and gadolinium oxide nanoparticles for potential bio-imaging applications

Weir, Charles (2015) Development of microwave synthetic routes to silica and gadolinium oxide nanoparticles for potential bio-imaging applications. Master of Science by Research (MScRes) thesis, University of Kent,. (KAR id:51035)

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Abstract

The main aim of this research was to develop microwave synthetic pathways to monodisperse silica nanoparticles, which have potential uses in bio-imaging. Functionalisation of these nanoparticles was also attempted, using the fluorescent dye, Rhodamine B. Microwave synthesis was also investigated as a route to metal oxide nanoparticles, specifically gadolinium oxide and doped-gadolinium oxide nanoparticles, which find uses as magnetic resonance contrast agents.

Fluorescent doping of silica nanoparticles was also demonstrated using the dye Rhodamine B. These particles were larger in size compared to the pure silica nanoparticles analogues, but remained highly fluorescent, even two months after synthesis.

Gadolinium oxide and europium-doped gadolinium oxide nanoparticles were also prepared using a combination of microwave irradiation and polyol synthesis. Both sets of particles displayed fluorescent properties, which could make them useful in future bioimaging applications.

Item Type: Thesis (Master of Science by Research (MScRes))
Thesis advisor: McCabe, Emma
Thesis advisor: Arnold, Donna C.
Uncontrolled keywords: silica microwave synthesis fluorescence DLS nanoparticles bioimaging biochemistry materials monodisperse SEM polyol Stober polydispersity PdI z-average gadolinium oxide europium
Subjects: Q Science > QC Physics > QC176.8.N35 Nanoscience, nanotechnology
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Users 1 not found.
Date Deposited: 15 Oct 2015 13:00 UTC
Last Modified: 01 Aug 2019 10:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/51035 (The current URI for this page, for reference purposes)
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