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Application of VRML for 3-dimensional, interactive, real-time comparison of OCT structure with standard histology

Tadrous, Paul J., Podoleanu, Adrian G.H., Dobre, George, Stamp, Gordon W.H. (2003) Application of VRML for 3-dimensional, interactive, real-time comparison of OCT structure with standard histology. In: SPIE Proceedings Series. 4956. pp. 42-49. Spie-Int Soc Optical Engineering (doi:10.1117/12.478933) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://www.dx.doi.org/10.1117/12.478933

Abstract

Optical coherence tomography (OCT) is a potentially useful 'optical biopsy' tool in medicine. To realise this potential doctors must be able to interpret OCT images with at least the same accuracy as conventional histology. It is therefore important that some accurate method of comparing OCT images with conventional histology be found. Despite numerous OCT vs. conventional histology studies in the literature the methods used for comparison have, by necessity, been approximate because it is not possible to cut a physical tissue section in the same plane as the OCT optical section (partly due to histology processing artefacts). In this paper we present a method of rendering solid tissue volumes with semi-transparency using the Virtual Reality Modelling Language (VRML) and devise a VRML script which allows any two volume data sets to be manipulated within the same region of virtual space. This allows the structure of a whole volume of tissue imaged with OCT to be directly compared with the serial section reconstruction of the conventionally stained histology. As the whole volume is visualised any corresponding tissue regions can be more easily identified despite tissue processing artefacts. We demonstrate the effectiveness of our method using an ex vivo biopsy of human breast carcinoma.

Item Type: Conference or workshop item (Proceeding)
DOI/Identification number: 10.1117/12.478933
Uncontrolled keywords: Biopsy ; Breast ; Medicine ; Modeling ; Optical coherence tomography ; Tissues ; Transparency ; Virtual reality
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 27 Jul 2015 09:14 UTC
Last Modified: 01 Aug 2019 10:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49792 (The current URI for this page, for reference purposes)
Dobre, George: https://orcid.org/0000-0002-5695-2591
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