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OCT imaging of the larynx: A feasibility study

Bibas, A.G., Podoleanu, Adrian G.H., Cucu, R.G., Bonmarin, M., Dobre, George, Ward, V., O'Dell, E., Boxer, A., Gleeson, M.J., Jackson, David A. and others. (2003) OCT imaging of the larynx: A feasibility study. In: SPIE Proceedings Series. Proceedings of SPIE - The International Society for Optical Engineering. 4956. pp. 95-100. Spie-Int Soc Optical Engineering (doi:10.1117/12.477886) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:49791)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
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Laryngeal cancer is the most common primary head and neck malignancy and the need for early identification is very important for early treatment. Outpatient fiberoptic examination of the larynx is often unreliable in differentiating between benign, pre-malignant and malignant lesions, and therefore surgeons often have to rely on biopsies for a definite diagnosis. This is an invasive procedure requiring general anaesthesia and may have a detrimental effect on patient's voice. The aim of our study was to investigate the feasibility of optical coherence tomography in imaging of the larynx, which will lay the foundations for investigating its ability to differentiate between benign and malignant disease. Tissue specimens from normal larynges were imaged with a polarisation sensitive OCT system at 850 nm and a second OCT system at 1300 nm. Both OCT systems were capable of providing both B-scan (longitudinal OCT) images as well as C-scan (en-face OCT or at constant depth) images. Imaged specimens were processed with standard histopathological techniques and sectioned in the plane of the B-scan OCT images. Haematoxylin-Eosin stained specimens were compared to the OCT images. Preliminary results showed good correlation between OCT images and histology sections in normal tissues.

Item Type: Conference or workshop item (Proceeding)
DOI/Identification number: 10.1117/12.477886
Uncontrolled keywords: Larynx, OCT, Biological organs, Biomedical engineering, Coherent light, Oncology, Pathology, Patient treatment, Tissue, Tomography, Histopathological techniques, Laryngeal cancer, Larynx, Malignancy, Optical coherence tomography, Medical imaging
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical instruments
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: Giles Tarver
Date Deposited: 24 Jul 2015 16:18 UTC
Last Modified: 16 Nov 2021 10:20 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Podoleanu, Adrian G.H..

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Dobre, George.

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Jackson, David A..

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