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3-D optical coherence tomography of the laryngeal mucosa

Bibas, A.G., Podoleanu, Adrian G.H., Cucu, R.G., Bonmarin, M., Dobre, George, Ward, V.M.M., Odell, E., Boxer, A., Gleeson, M.J., Jackson, David A. and others. (2004) 3-D optical coherence tomography of the laryngeal mucosa. Clinical Otolaryngology, 29 (6). pp. 713-720. ISSN 0307-7772. (doi:10.1111/j.1365-2273.2004.00902.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1111/j.1365-2273.2004.00902.x

Abstract

Laryngeal carcinoma is one of the commonest primary head and neck malignancy and the need for early identification is very important for successful treatment. Outpatient fibreoptic examination of the larynx is unreliable in differentiating benign, pre-malignant and malignant lesions, and therefore surgeons have to rely on biopsies for a definitive diagnosis. This is an invasive procedure requiring general anaesthesia and may have a detrimental effect on the patient's voice. Conventional imaging modalities (ultrasound, computed tomography and magnetic resonance imaging) have a limited resolution and hence cannot give sufficient information on the extent or nature of laryngeal lesions. The aim of our study is to investigate the feasibility of optical coherence tomography (OCT) in imaging the normal larynx, to lay the foundations for an investigation of its ability to differentiate between benign and malignant disease. Ten tissue specimens from normal larynges were imaged with an 850 nm OCT system that was capable of providing both B-scan (longitudinal or cross-section) images as well as C-scan (en-face or images at constant depth). The en-face OCT mode allowed us to reconstruct 3-D OCT images of the tissue examined. Imaged specimens were processed with standard histopathological techniques and sectioned in the plane of the B-scan OCT images. Haematoxylin-eosin stained specimens were compared with the OCT images thus collected. Preliminary results showed good correlation between OCT images and histology sections in normal tissue.

Item Type: Article
DOI/Identification number: 10.1111/j.1365-2273.2004.00902.x
Additional information: This is available as OPEN ACCESS by clicking on the URL.
Uncontrolled keywords: Imaging, Larynx, Optical coherence tomography, eosin, hematoxylin, B scan, benign tumor, comparative study, conference paper, early diagnosis, feasibility study, head and neck cancer, histology, histopathology, human, human tissue, laryngeal biopsy, laryngoscopy, larynx carcinoma, larynx mucosa, malignant neoplastic disease, nuclear magnetic resonance imaging, optical coherence tomography, precancer, priority journal, staining, three dimensional imaging, tumor differentiation, ultrasound, Humans, Imaging, Three-Dimensional, Laryngeal Mucosa, Laryngeal Neoplasms, Laryngectomy, Magnetic Resonance Imaging, Neoplasm Invasiveness, Tomography, Optical Coherence
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 24 Jul 2015 16:05 UTC
Last Modified: 01 Aug 2019 10:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49782 (The current URI for this page, for reference purposes)
Dobre, George: https://orcid.org/0000-0002-5695-2591
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