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Ultrahigh-resolution combined coronal optical coherence tomography confocal scanning ophthalmoscope (OCT/SLO): A pilot study

Rosen, R.B., Van Velthoven, M.E.J., Garcia, P.M.T., Cucu, R.G., De Smet, M.D., Muldoon, T.O., Podoleanu, Adrian G.H. (2007) Ultrahigh-resolution combined coronal optical coherence tomography confocal scanning ophthalmoscope (OCT/SLO): A pilot study. Spektrum der Augenheilkunde, 21 (1). pp. 17-28. ISSN 0930-4282. (doi:10.1007/s00717-007-0182-4) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1007/s00717-007-0182-4

Abstract

Objective: To evaluate clinical images from a prototype ultrahigh resolution (UHR) combined coronal optical coherence tomography/confocal scanning ophthalmoscope (OCT/SLO) and to compare them to standard-resolution OCT/SLO images on the same patients. Design: Cross-sectional pilot-study. Participants: Sixty-six eyes of 42 patients with various macular pathologies, such as age-related macular degeneration, macular edema, macular hole, central serous retinopathy, epiretinal membrane and posterior vitreous traction syndrome. Methods: Each subject was first scanned with a standard-resolution OCT/SLO that has an axial resolution of ?10 micron. Immediately following, patients were scanned with the prototype UHR OCT/SLO device. The UHR system employs a compact super luminescent diode (SLD) with a 150 nm bandwidth centered at 890 nm, which allows imaging of the retina with an axial resolution of 3 microns. Both coronal and longitudinal OCT scans were acquired with each system, and compared side-by-side. Scan quality was assessed for the observer's ability to visualize the vitreo-retinal interface and retinal layers - in particular of the outer retina/RPE/choroidal interface, increased discrimination of pathological changes, and better signal intensity. Main outcome measures: Ultrahigh and standard-resolution coronal and longitudinal OCT/SLO images of macular pathologies. Results: In the side-by-side comparison with the commercial standard-resolution OCT/SLO images, the scans in the Ultrahigh resolution OCT/SLO images were superior in 85% of cases. Relatively poor quality images were attributed to lower signal-to-noise ratio, limited focusing, or media opacities. Several images that had a better signal intensity in the standard-resolution OCT/SLO system were found to show more retinal detail in the UHR system. In general, intraretinal layers in the UHR OCT/SLO images were better delineated in both coronal and longitudinal scans. Enhanced details were also seen in the outer retina/RPE/choroidal complex. The UHR OCT/SLO system produced better definition of morphological changes in several macular pathologies. Conclusions: Broadband SLD-based UHR OCT/SLO offers a compact, efficient, and economic enhancement to the currently available clinical OCT imaging systems. UHR OCT/SLO imaging enhanced the quality of the OCT C-scans, facilitated appreciation of vitreo-retinal pathologies, and improved sensitivity to small changes in the retina, and the outer retina/RPE/choroidal interface.

Item Type: Article
DOI/Identification number: 10.1007/s00717-007-0182-4
Additional information: This is available as OPEN ACCESS by clicking on the URL.
Uncontrolled keywords: Coronal OCT, OCT ophthalmoscope, OCT/SLO, Ultrahigh resolution OCT
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 24 Jul 2015 14:17 UTC
Last Modified: 29 May 2019 14:54 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49744 (The current URI for this page, for reference purposes)
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