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En-face differential absorption optical coherence tomography with gold nanorods as the contrast agent

Leitner, M., Henkel, A., Sonnichsen, C., Rosa, C.C., Podoleanu, Adrian G.H. (2008) En-face differential absorption optical coherence tomography with gold nanorods as the contrast agent. In: SPIE Proceedings Series. 7139. Spie-Int Soc Optical Engineering ISBN 978-0-8194-7380-6. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
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Abstract

A new variety of nanoparticles showing unique and characteristic optical properties, appeals for its use as contrast agents in medical imaging. Gold nanospheres, nanorods and nanoshells with a silica core are new forms of promising contrast agents which can be tuned to specific absorption or scattering characteristics within the near-infrared (NIR) spectrum ranging from 650 - 1300 nm. They have the ability to be used for both image enhancement and as photosensitive markers due to their well designable scattering and absorption properties. Furthermore, their strong optical absorption permits treatment of malignant cells by photoablation processes, induced when heating them with a matched light source. Differential absorption optical coherence tomography (DA-OCT) allows for the detection and depth resolved concentration measurement of such markers. So far, reports on DA-OCT systems used A-scan based imaging systems to assess depth resolved information about the absorption properties and the concentration of a chemical compound. Enface OCT (B(T) or C(T) scan based) images allow for better depth localization and a depth resolved concentration measurement of the compound under investigation. For this aim, we evaluate the suitability of a multiscan time-domain OCT set-up, compatible with different light sources providing different wavelengths and bandwidths in the NIR, to perform differential absorption OCT measurements, using gold nanorods as the contrast agent.

Item Type: Conference or workshop item (Proceeding)
Uncontrolled keywords: Differential absorption OCT; En-face OCT; Gold nanorods; Optical coherence tomography; Time-domain OCT
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 24 Jul 2015 11:12 UTC
Last Modified: 29 May 2019 14:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49704 (The current URI for this page, for reference purposes)
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