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Hydrazinonicotinic acid (HYNIC) - Coordination chemistry and applications in radiopharmaceutical chemistry

Meszaros, L.K., Dose, A., Biagini, S.C.G., Blower, P.J. (2010) Hydrazinonicotinic acid (HYNIC) - Coordination chemistry and applications in radiopharmaceutical chemistry. Inorganica Chimica Acta, 363 (6). pp. 1059-1069. ISSN 00201693 (ISSN). (doi:10.1016/j.ica.2010.01.009) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

HYNIC (hydrazinonicotinamide) is an efficient bifunctional chelator for Tc-99m used for labelling biomolecules for molecular imaging. Developments and enhancements to improve its efficacy and versatility, including applications beyond Tc-99m labelling, include designs to allow site specificity, availability of amino acid building blocks, improved protecting groups, and a varied choice of co-ligands. In this review, these enhancements are summarised, along with an assessment of the opportunities afforded and problems posed by the use of HYNIC, a discussion of its coordination mode, and the prospects for improving its use and overcoming some of the limitations. There is now an opportunity to exploit the excellent labelling kinetics associated with the tricine-HYNIC system with better co-ligand design to enable both efficient production of labelled proteins and peptides and better specific activity and in vivo properties. In summary, HYNIC represents a well-established way to exploit the highly reactive hydrazine group, to generate bioconjugate chemistry with a degree of bioorthogonality offering the possibility for highly efficient and site specific modification of biomolecules for imaging. © 2010 Elsevier B.V. All rights reserved.

Item Type: Article
DOI/Identification number: 10.1016/j.ica.2010.01.009
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Inorg. Chim. Acta [Field not mapped to EPrints] AD - King's College London, Division of Imaging Sciences, Rayne Institute, 4th Floor Lambeth Wing, London, SE1 7EH, United Kingdom [Field not mapped to EPrints] AD - University of Kent, School of Physical Sciences, Canterbury, CT2 7NH, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: Hydrazinonicotinamide, HYNIC, Radiopharmaceutical, Technetium
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General) > R895 Nuclear Medicine
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Giles Tarver
Date Deposited: 21 Jul 2015 10:50 UTC
Last Modified: 29 May 2019 14:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49612 (The current URI for this page, for reference purposes)
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