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Surface functionalisation of magnetic nanoparticles: Quantification of surface to bulk amine density

Van De Waterbeemd, M., Sen, T., Biagini, S.C.G., Bruce, Ian J. (2010) Surface functionalisation of magnetic nanoparticles: Quantification of surface to bulk amine density. Micro and Nano Letters, 5 (5). pp. 282-285. ISSN 1750-0443. (doi:10.1049/mnl.2010.0112) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1049/mnl.2010.0112

Abstract

Work has been conducted to adapt a colourimetric assay previously used on flat surfaces for the assay of amine group density on nanoparticles silanised with 3-(aminopropyl) triethoxysilane. The new assay was rapid, easy to perform, and linear in the range of optical density (OD282nm) values of 0.080-1.6 for particle suspension densities of between 0.5 and 7.0mg/ml. In addition, the same materials, as well as the ones activated using 3-(aminopropyl) diethoxy methyl silane, were investigated for their elemental compositions by, combustion carbon-hydrogen-nitrogen (CHN) analysis and results from both approaches together have permitted the accurate calculation of the ratio of surface to total amine density for the materials when activated in water. This value can in turn be used as an indication of a surface amino structure (i.e. mono or multilayer). The aminosilanisation processes were further characterised by DNA-binding/elution and zeta potential measurement. This combination of approaches provides a fast, convenient and effective means of measuring surface amine densities on particles and yields information about the structure of the surface aminosilanes layers. © 2010 The Institution of Engineering and Technology.

Item Type: Article
DOI/Identification number: 10.1049/mnl.2010.0112
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Micro. Nano. Lett. [Field not mapped to EPrints] AD - Nanobiotechnology Research Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom [Field not mapped to EPrints] AD - Centre for Materials Science, School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, PR1 2HE, United Kingdom [Field not mapped to EPrints] AD - School of Physical Sciences, Ingram Building, University of Kent, Canterbury, Kent CT2 7NH, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: Amine groups, Aminopropyl, Aminosilanes, Elemental compositions, Flat surfaces, Magnetic nanoparticles, Optical densities, Particle suspensions, Surface amine density, Surface functionalisation, Triethoxysilane, Zeta potential measurements, Nanomagnetics, Nanoparticles, Organic compounds, Silanes, Suspensions (fluids), Zeta potential, Surface structure, 3 aminopropyldiethoxymethylsilane, 3 aminopropyltriethoxysilane, amine, carbon, nanoparticle, nitrogen, silane derivative, unclassified drug, article, bulk density, chemical analysis, colorimetry, DNA binding, quantitative analysis, surface property, suspension, zeta potential
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Giles Tarver
Date Deposited: 21 Jul 2015 10:48 UTC
Last Modified: 15 Jan 2020 04:06 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49611 (The current URI for this page, for reference purposes)
Biagini, S.C.G.: https://orcid.org/0000-0002-4713-5127
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