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Inorganic approaches for radiolabelling biomolecules with fluorine-18 for imaging with Positron Emission Tomography

Smith, G.E., Sladen, H.L., Biagini, S.C.G., Blower, P.J. (2011) Inorganic approaches for radiolabelling biomolecules with fluorine-18 for imaging with Positron Emission Tomography. Dalton Transactions, 40 (23). pp. 6196-6205. ISSN 14779226 (ISSN). (doi:10.1039/c0dt01594f) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1039/c0dt01594f

Abstract

Conventional methods for radiolabelling biomolecules such as proteins and peptides with fluorine-18 for PET imaging rely on carbon-fluorine bond formation and are complex and inefficient. Several non-carbon elements form strong bonds (i.e. with high bond enthalpy) with fluorine, but with lower activation energy for their formation compared to carbon-fluorine bonds, whilst preserving a relatively high kinetic stability. In particular, by incorporating boron-, aluminium- and silicon-containing prosthetic groups into biomolecules, promising results have recently been achieved in the radiolabelling with F-18-fluoride under mild aqueous conditions, affording a level of convenience, efficiency and specific activity potentially superior to those offered by conventional C-F bond formation methods. The promise already shown by these early studies heralds a new branch of bioconjugate radiochemistry involving a wider range of "fluoridephilic" elements for synthesis of PET molecular imaging agents. © 2011 The Royal Society of Chemistry.

Item Type: Article
DOI/Identification number: 10.1039/c0dt01594f
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Dalton Trans. [Field not mapped to EPrints] C2 - 21499604 [Field not mapped to EPrints] AD - King's College London, Division of Imaging Sciences, St Thomas' Hospital, Lambeth Wing, London SE1 7EH, United Kingdom [Field not mapped to EPrints] AD - Functional Materials Group, School of Physical Sciences, University of Kent, Canterbury CT2 7NJ, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: Aqueous condition, Bioconjugates, Bond formation, C-F bonds, Conventional methods, Fluorine-18, Kinetic stability, Molecular imaging, PET imaging, Prosthetic groups, Radiolabelling, Specific activity, Activation energy, Biomolecules, Boron, Boron compounds, Fluorine, Proteins, Positron emission tomography, aluminum, boron, chelating agent, fluorine, radiopharmaceutical agent, silicon, animal, chemistry, isotope labeling, mouse, positron emission tomography, review, tissue distribution, Aluminum, Animals, Boron, Chelating Agents, Fluorine Radioisotopes, Isotope Labeling, Mice, Positron-Emission Tomography, Radiopharmaceuticals, Silicon, Tissue Distribution
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General) > R895 Nuclear Medicine
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Giles Tarver
Date Deposited: 21 Jul 2015 10:58 UTC
Last Modified: 29 May 2019 14:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49609 (The current URI for this page, for reference purposes)
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