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Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly

Edwardson, T.G.W., Carneiro, K.M.M., McLaughlin, C.K., Serpell, C.J., Sleiman, H.F. (2013) Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly. Nature Chemistry, 5 (10). pp. 868-875. ISSN 17554330 (ISSN). (doi:10.1038/nchem.1745) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

Nature uses a combination of non-covalent interactions to create a hierarchy of complex systems from simple building blocks. One example is the selective association of the hydrophobic side chains that are a strong determinant of protein organization. Here, we report a parallel mode of assembly in DNA nanotechnology. Dendritic alkyl-DNA conjugates are hybridized to the edges of a DNA cube. When four amphiphiles are on one face, the hydrophobic residues of two neighbouring cubes engage in an intermolecular 'handshake', resulting in a dimer. When there are eight amphiphiles (four on the top and bottom cube faces, respectively), they engage in an intramolecular 'handshake' inside the cube. This forms the first example of a monodisperse micelle within a DNA nanostructure that encapsulates small molecules and releases them by DNA recognition. Creating a three-dimensional pattern of hydrophobic patches, like side chains in proteins, can result in specific, directed association of hydrophobic domains with orthogonal interactions to DNA base-pairing. © 2013 Macmillan Publishers Limited. All rights reserved.

Item Type: Article
DOI/Identification number: 10.1038/nchem.1745
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Nat. Chem. [Field not mapped to EPrints] C2 - 24056344 [Field not mapped to EPrints] AD - Department of Chemistry and Centre for Self-assembled Chemical Structures, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A2K6, Canada [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: dendrimer, DNA, article, chemical phenomena, chemical structure, chemistry, micelle, two dimensional gel electrophoresis, Dendrimers, DNA, Electrophoresis, Gel, Two-Dimensional, Hydrophobic and Hydrophilic Interactions, Micelles, Models, Molecular
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Giles Tarver
Date Deposited: 10 Jul 2015 15:53 UTC
Last Modified: 23 Jan 2020 04:10 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49479 (The current URI for this page, for reference purposes)
Serpell, C.J.: https://orcid.org/0000-0002-2848-9077
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