Ex-vivo endoscopic laryngeal cancer imaging using two forward-looking fiber optic scanning endoscope probes

Cernat, Ramona and Tatla, T. and Pang, J.-Y. and Tadrous, P.J. and Gelikonov, G. and Gelikonov, V. and Zhang, Y.Y. and Bradu, Adrian and Li, X.D. and Podoleanu, Adrian G.H. (2012) Ex-vivo endoscopic laryngeal cancer imaging using two forward-looking fiber optic scanning endoscope probes. In: Optics in Health Care and Biomedical Optics V. Optics in Health Care and Biomedical Optics V. Spie-Int Soc Optical Engineering ISBN 978-0-8194-9308-8. (doi:https://doi.org/10.1117/12.999905) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1117/12.999905

Abstract

Larynx cancer is one of the most common primary head and neck cancers. For early-stage laryngeal cancer, both surgery and radiotherapy are effective treatment modalities, offering a high rate of local control and cure. Optical coherence tomography (OCT) is an established non-invasive optical biopsy method, capable of imaging ranges of 2- 3 mm into tissue. By using the principles of low coherence light interferometry, OCT can be used to distinguish normal from unhealthy laryngeal mucosa in patients. Two forward-looking endoscope OCT probes of different sizes in a sweeping frequency OCT (SS-OCT) configuration were compared in terms of their performances for ex-vivo laryngeal cancer imaging. The setup configuration of the first OCT probe unit was designed and constructed at the Institute of Applied Physics RAS, Russia (diameter of 1.9 mm and the rigid part at the distal end is 13 mm long). The second OCT endoscope probe was constructed at the Department of Biomedical Engineering at Johns Hopkins University, USA, using a tubular piezoelectric actuator with quartered electrodes in combination with a resonant fiber cantilever (diameter of 2.4 mm, and rigid part of 45 mm). Cross-sectional images of laryngeal lesions using the two OCT configurations were aquired and compared with OCT images obtained in a 1310 nm SS-OCT classical non-endoscopic system. The work presented here is an intermediate step in our research towards in-vivo endoscopic laryngeal cancer imaging. © Copyright SPIE.

Item Type: Conference or workshop item (Proceeding)
Uncontrolled keywords: endoscopy, ex-vivo imaging, fiber optic endoscope probes, optical coherence tomography, Cross sectional image, Ex-vivo, Fiber optic endoscopes, Head-and-neck cancer, Johns hopkins universities, Light interferometry, Sweeping frequencies, Treatment modality, Diseases, Health care, Medical imaging, Optical tomography, Optics, Piezoelectric actuators, Probes, Tissue, Endoscopy
Subjects: Q Science > QC Physics
Q Science > QC Physics > QC355 Optics
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 16 Jul 2015 10:56 UTC
Last Modified: 21 Jul 2015 13:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49367 (The current URI for this page, for reference purposes)
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