Canjau, S., Todea, C., Sinescu, C., Negrutiu, M.L., Duma, V., Manescu, A., Topala, F.I., Podoleanu, Adrian G.H. (2013) Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography. In: European Conference on Biomedical Optics. European Conference on Biomedical Optics. . Optical Society of America ISBN 978-0-8194-9646-1. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:49356)
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Abstract
The efforts aimed at early diagnosis of oral cancer should be prioritized towards developing a new screening instrument, based on optical coherence tomography (OCT), to be used directly intraorally, able to perform a fast, real time, 3D and non-invasive diagnosis of oral malignancies. The first step in this direction would be to optimize the OCT image interpretation of oral tissues. Therefore we propose plastination as a tissue preparation method that better preserves three-dimensional structure for study by new optical imaging techniques. The OCT and the synchrotron radiation computed microtomography (micro-CT) were employed for tissue sample analyze. For validating the OCT results we used the gold standard diagnostic procedure for any suspicious lesion - histopathology. This is a preliminary study of comparing features provided by OCT and Micro-CT. In the conditions of the present study, OCT proves to be a highly promising imaging modality. The use of x-ray based topographic imaging of small biological samples has been limited by the low intrinsic x-ray absorption of non-mineralized tissue and the lack of established contrast agents. Plastination can be used to enhance optical imagies of oral soft tissue samples. © 2013 OSA-SPIE.
Item Type: | Conference or workshop item (Proceeding) |
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Uncontrolled keywords: | Micro-CT; Minimally-invasive diagnosis; Optical coherence tomography; Oral squamous cell carcinoma; Plastination |
Subjects: |
Q Science > QC Physics R Medicine > R Medicine (General) > R857.O6 Optical instruments |
Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
Depositing User: | Giles Tarver |
Date Deposited: | 16 Jul 2015 09:50 UTC |
Last Modified: | 16 Feb 2021 13:26 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/49356 (The current URI for this page, for reference purposes) |
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