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Full-field thickness distribution of human tympanic membrane obtained with optical coherence tomography

Van Der Jeught, S., Dirckx, J.J.J., Aerts, J.R.M., Bradu, Adrian, Podoleanu, Adrian G.H., Buytaert, J.A.N. (2013) Full-field thickness distribution of human tympanic membrane obtained with optical coherence tomography. JARO - Journal of the Association for Research in Otolaryngology, 14 (4). pp. 483-494. ISSN 1525-3961. (doi:10.1007/s10162-013-0394-z) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

The full-field thickness distribution, three-dimensional surface model and general morphological data of six human tympanic membranes are presented. Cross-sectional images were taken perpendicular through the membranes using a high-resolution optical coherence tomography setup. Five normal membranes and one membrane containing a pathological site are included in this study. The thickness varies strongly across each membrane, and a great deal of inter-specimen variability can be seen in the measurement results, though all membranes show similar features in their respective relative thickness distributions. Mean thickness values across the pars tensa ranged between 79 and 97 μm; all membranes were thinnest in the central region between umbo and annular ring (50-70 μm), and thickness increased steeply over a small distance to approximately 100-120 μm when moving from the central region either towards the peripheral rim of the pars tensa or towards the manubrium. Furthermore, a local thickening was noticed in the antero-inferior quadrant of the membranes, and a strong linear correlation was observed between inferior-posterior length and mean thickness of the membrane. These features were combined into a single three-dimensional model to form an averaged representation of the human tympanic membrane. 3D reconstruction of the pathological tympanic membrane shows a structural atrophy with retraction pocket in the inferior portion of the pars tensa. The change of form at the pathological site of the membrane corresponds well with the decreased thickness values that can be measured there. © 2013 Association for Research in Otolaryngology.

Item Type: Article
DOI/Identification number: 10.1007/s10162-013-0394-z
Additional information: Embargo period ended August 2014.
Uncontrolled keywords: 3D model, eardrum, finite element modeling, OCT, pars tensa, article, confocal microscopy, cross-sectional study, eardrum, human, human tissue, image processing, light, optical coherence tomography, priority journal, refraction index, sound transmission, temporal bone, thickness, tympanic membrane thickness, Biomechanical Phenomena, Cadaver, Finite Element Analysis, Humans, Models, Anatomic, Tomography, Optical Coherence, Tympanic Membrane
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 16 Jul 2015 08:48 UTC
Last Modified: 29 May 2019 14:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49331 (The current URI for this page, for reference purposes)
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