Skip to main content

Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography

Cânjău, Silvana and Todea, Carmen and Sinescu, Cosmin and Negruţiu, Meda L. and Duma, Virgil and Mănescu, Adrian and Topală, Florin I. and Podoleanu, Adrian Gh. (2013) Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography. In: Head and Neck Optical Diagnostics. Proceedings of SPIE . SPIE. ISBN 978-0-8194-9650-8. (doi:10.1117/12.2032584) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://www.dx.doi.org/10.1117/12.2032584

Abstract

The efforts aimed at early diagnosis of oral cancer should be prioritized towards developing a new screening instrument, based on optical coherence tomography (OCT), to be used directly intraorally, able to perform a fast, real time, 3D and non-invasive diagnosis of oral malignancies. The first step in this direction would be to optimize the OCT image interpretation of oral tissues. Therefore we propose plastination as a tissue preparation method that better preserves three-dimensional structure for study by new optical imaging techniques. The OCT and the synchrotron radiation computed microtomography (micro-CT) were employed for tissue sample analyze. For validating the OCT results we used the gold standard diagnostic procedure for any suspicious lesion - histopathology. This is a preliminary study of comparing features provided by OCT and Micro-CT. In the conditions of the present study, OCT proves to be a highly promising imaging modality. The use of x-ray based topographic imaging of small biological samples has been limited by the low intrinsic x-ray absorption of non-mineralized tissue and the lack of established contrast agents. Plastination can be used to enhance optical imagies of oral soft tissue samples.

Item Type: Book section
DOI/Identification number: 10.1117/12.2032584
Additional information: Unmapped bibliographic data: C7 - 880504 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Progr. Biomed. Opt. Imaging Proc. SPIE [Field not mapped to EPrints] AD - Faculty of Dentistry, University of Medicine and Pharmacy Timisoara, Romania [Field not mapped to EPrints] AD - Deparment of Product Design, Faculty of Engineering, Aurel Vlaicu University, Arad, Romania [Field not mapped to EPrints] AD - Deparment D.I.S.C.O., Section of Physical Sciences, Universita Politecnica Delle Marche, Ancona, Italy [Field not mapped to EPrints] AD - Applied Optics Group, School of Physical Sciences, University of Kent, Canterbury, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] A4 - The Optical Society; The Society of Photo-Optical Instrumentation Engineers (SPIE) [Field not mapped to EPrints] C3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE [Field not mapped to EPrints]
Uncontrolled keywords: Micro-CT, minimally-invasive diagnosis, optical coherence tomography, Oral squamous cell carcinoma, plastination, Computed microtomography, Micro CT, Non-invasive diagnosis, Optical imaging technique, Oral squamous cell carcinomata, plastination, Screening instruments, Three-dimensional structure, Computerized tomography, Imaging techniques, Optical image storage, Optical tomography, Synchrotron radiation, Three dimensional, Tissue, Tissue engineering
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 15 Jul 2015 09:33 UTC
Last Modified: 26 Jul 2019 09:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49324 (The current URI for this page, for reference purposes)
  • Depositors only (login required):