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Imaging of oral pathological tissue using optical coherence tomography

Canjau, Silvana and Todea, Carmen and Sinescu, Cosmin and Duma, Virgil-Florin and Topala, Florin Ionel and Podoleanu, Adrian Gh. (2014) Imaging of oral pathological tissue using optical coherence tomography. In: Fifth International Conference on Lasers in Medicine: Biotechnologies Integrated in Daily Medicine. Proceedings of SPIE . SPIE, Bellingham, Washington. ISBN 978-0-8194-9817-5. (doi:10.1117/12.2041752) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:49315)

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Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images. The elements obserced included extensive epithelial down-growth, the disruption of the basement membrane, with areas of erosion, an epithelial layer that was highly variable in thickness and invasion into the sub-epithelial layers. Therefore, OCT appears to be a highly promising imaging modality.

Item Type: Book section
DOI/Identification number: 10.1117/12.2041752
Additional information: Unmapped bibliographic data: C7 - 89250X [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Progr. Biomed. Opt. Imaging Proc. SPIE [Field not mapped to EPrints] AD - Faculty of Dentistry, University of Medicine and Pharmacy, Timisoara, Romania [Field not mapped to EPrints] AD - 3OM Optomechatronics Group, Faculty of Engineering, Aurel Vlaicu University of Arad, Romania [Field not mapped to EPrints] AD - Applied Optics Group, School of Physical Sciences, University of Kent, Canterbury, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] A4 - Romanian Society for Lasers in Dentistry (SRLS) [Field not mapped to EPrints] C3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE [Field not mapped to EPrints]
Uncontrolled keywords: minimally-invasive diagnosis, optical coherence tomography, Oral squamous cell carcinoma, Biotechnology, Diagnosis, Histology, Tissue, Basement membrane, Epithelial down-growth, Non-invasive diagnosis, Optical technique, Oral squamous cell carcinomata, Pathological tissue, Realtime imaging, Tissue structure, Optical tomography
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical instruments
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Giles Tarver
Date Deposited: 15 Jul 2015 09:06 UTC
Last Modified: 16 Feb 2021 13:26 UTC
Resource URI: (The current URI for this page, for reference purposes)
Podoleanu, Adrian Gh.:
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